U.S. models
If you replace a flat tire with the spare tire, the low tire pressure/TPMS indicator comes on while you are driving. After driving for a few miles (kilometers), the indicator will start blinking for a short time and then stay on. Tire Pressures Low appears on the driver information interface*, but this is normal.
Calibrate the TPMS when you replace the tire with a specified regular tire.
The system cannot monitor the pressure of the spare tire. Manually check the spare tire pressure to be sure that it is correct.
Honda Civic Owners Manual. Safety Checklist
For the safety of you and your passengers, make a habit of checking these
items
each time before you drive.
After everyone has entered the vehicle, be sure all doors are closed and
locked.
Locking the doors helps prevent an occupant from being ejected and an outsider
from unexpectedly open ...